yulius hermantoHygiene not always good for your health!
April 24th 2009 05:44
Introduction
Hygiene is being known for long time as basic prevention of infectious disease. I also agree with that, because lots of evidence related with that. Infection cases are higher in poor hygiene area.
So, where is the point of bad? The cost? or what?
In to the Depth
Until know, it is still just a hypothesis about impact of hygiene of health. First, i have to explain about immune system because it's related. Our immune system main function is to protect against harmful things, whether it is a infectious agent, or maybe foreign body.
In our immune system, we know there is two kind of polarity, whether is TH1 or TH2, in simple words cellular mediated or humoral immunity.
What is the relation between hygiene and immune?
It's being hypothesize that hygiene condition make our immune system shift it's polarization to humoral. In simple words, hygiene make our soldier don't fight, so they become lack of knowledge of war.
The impact of this is a disease related to immune. That is an allergy. "Lack of knowledge of war" makes our immune missrecognized the "enemy" ( harmful things). They overreact to non-harmful stimulus. Allergy disease is cause not by the stimulus but by inflammatory reaction. Our immune system produce to many IgE that responsible for mast cell activation that will produce inflammatory effects.
This is being known as hygiene hypothesis, you search in the literature about it.
That's why allergy more often seen in developed country than underdeveloped country
Choice to made
We want to have allergy or infection? Like the egg on edge.
Both of them, have own consequences. Infection maybe seems to be dangerous and cause more morbidity. But several infection provides protection from re- infection, not like allergy.
Asthma, allergic rhinitis, dermatitis allergy also brings impacts to quality of life.
From my point of view, our nature prefer middle path rather than extreme sides. It's not to avoid the diseases, but to assure the well living as human.
Related news
Based on hygiene hypothesis, one of allergy treatment modalities is "infects" the patient with the worms. Eventhough, the antibody is about same in worms infections (IgE) but the interaction (cytokine) is different and the cytokines in worms infections can suppressed the polarity to the allergy. But you should check the literature for that.
Thank you before.
References
1. Cotran, Kumar, Collins: Robbins Pathologic Basis of Disease, 1999.
2. Benjamin, E. Sunshine, G. Leskowitz, S.: Immunology A short Course, 1996.
3. Durham, SR. et al., Long-term clinical efficacy of grass-pollen immunotherapy. The New Eng J Med 1999; 341(7): 468-475.
Hygiene is being known for long time as basic prevention of infectious disease. I also agree with that, because lots of evidence related with that. Infection cases are higher in poor hygiene area.
So, where is the point of bad? The cost? or what?
In to the Depth
Until know, it is still just a hypothesis about impact of hygiene of health. First, i have to explain about immune system because it's related. Our immune system main function is to protect against harmful things, whether it is a infectious agent, or maybe foreign body.
What is the relation between hygiene and immune?
It's being hypothesize that hygiene condition make our immune system shift it's polarization to humoral. In simple words, hygiene make our soldier don't fight, so they become lack of knowledge of war.
The impact of this is a disease related to immune. That is an allergy. "Lack of knowledge of war" makes our immune missrecognized the "enemy" ( harmful things). They overreact to non-harmful stimulus. Allergy disease is cause not by the stimulus but by inflammatory reaction. Our immune system produce to many IgE that responsible for mast cell activation that will produce inflammatory effects.
That's why allergy more often seen in developed country than underdeveloped country
Choice to made
We want to have allergy or infection? Like the egg on edge.
Both of them, have own consequences. Infection maybe seems to be dangerous and cause more morbidity. But several infection provides protection from re- infection, not like allergy.
Asthma, allergic rhinitis, dermatitis allergy also brings impacts to quality of life.
From my point of view, our nature prefer middle path rather than extreme sides. It's not to avoid the diseases, but to assure the well living as human.
Related news
Based on hygiene hypothesis, one of allergy treatment modalities is "infects" the patient with the worms. Eventhough, the antibody is about same in worms infections (IgE) but the interaction (cytokine) is different and the cytokines in worms infections can suppressed the polarity to the allergy. But you should check the literature for that.
Thank you before.
References
1. Cotran, Kumar, Collins: Robbins Pathologic Basis of Disease, 1999.
2. Benjamin, E. Sunshine, G. Leskowitz, S.: Immunology A short Course, 1996.
3. Durham, SR. et al., Long-term clinical efficacy of grass-pollen immunotherapy. The New Eng J Med 1999; 341(7): 468-475.
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