yulius hermanto
Adding Fish Oil to Low-Fat/High-Carb Diet May Improve Cholesterol
In this article, i gonna discuss about AHA publication about Fish Oil and its beneficial effects on our health.
Fact or Hoax
Since the first American Heart Association recommend us to add fish oil to our diet cause its possible benefits. In 2002, AHA publish their large scale epidemiological research about fish oil benefits.
It had been said that there are significant effects of omega-3 (or n-3) fatty acids on cardiovascular disease (CVD) in patients with preexisting CVD as well as in
healthy individuals.
New information about how omega-3 fatty acids affect cardiac function (including antiarrhythmic effects), hemodynamics (cardiac mechanics), and arterial
endothelial function have helped clarify potential mechanisms of action.
Potential Benefits
Many epidemiological were being done to measure potential benefits of omega-3 and determine the optimum dose. Some older results show that a risk reduction in cardiovascular disease such as myocard infarction, sudden death and stroke or inverse association or maybe more easy to say as protective effect.
But few research also show that no significant risk reduction for cardiovascular events compare to people with normal diet.
So, it was planned to do more research about it. And it's done by randomized controlled trial (higher level of evidence in proofing). In aggregate, available RCTs show a beneficial effect of dietary and supplemental omega-3 fatty acids, including both EPA DHA and -linolenic acid, on Cardiovascular Disease.
Possible Mechanisms
- Reduce susceptibility of the heart to ventricular arrhythmia
- Antithrombogenic
- Hypotriglyceridemic (fasting and postprandial)
- Retard growth of atherosclerotic plaque
- Reduce adhesion molecule expression
- Reduce platelet-derived growth factor
- Antiinflammatory
- Promote nitric oxide-induced endothelial relaxation
- Mildly hypotensive
Side Effects and Safety
Several researchs are done to calculate optimal dose for its benefits.
Up to 1 g/d, there is a proven beneficial effects, and lower complication rates.
Above 3g/d, the complication effects overcome the benefits of the omega-3.
Some species of fish may contain significant levels of environmental contaminants. These substances bioconcentrate in the aquatic food chain such that levels are generally highest in older, larger, predatory fish and marine mammals.
These contaminants is longer half-life in the body and can accumulate in people who consume contaminated fish on a frequent basis and may impact our health.
For this may be, you should contact your dietitian our nutritionist, or is easier for you to choose a supplement.
Summary of Recommendation
Patients without documented CVD, Eat a variety of (preferably oily) fish at least twice a week. Include oils and foods rich in -linolenic acid (flaxseed, canola, and soybean oils; flaxseed and walnuts)
Patients with CVD, Consume up to 1 g of EPA DHA per day, preferably from oily fish. EPADHA supplementscould be considered in consultation with the physician.
Patients needing triglyceride lowering Two to four grams of EPADHA per day provided as capsules under a physician’s care.
Thank you for your appreciation.
Have a nice time
Fact or Hoax
Since the first American Heart Association recommend us to add fish oil to our diet cause its possible benefits. In 2002, AHA publish their large scale epidemiological research about fish oil benefits.
It had been said that there are significant effects of omega-3 (or n-3) fatty acids on cardiovascular disease (CVD) in patients with preexisting CVD as well as in
healthy individuals.
endothelial function have helped clarify potential mechanisms of action.
Potential Benefits
Many epidemiological were being done to measure potential benefits of omega-3 and determine the optimum dose. Some older results show that a risk reduction in cardiovascular disease such as myocard infarction, sudden death and stroke or inverse association or maybe more easy to say as protective effect.
So, it was planned to do more research about it. And it's done by randomized controlled trial (higher level of evidence in proofing). In aggregate, available RCTs show a beneficial effect of dietary and supplemental omega-3 fatty acids, including both EPA DHA and -linolenic acid, on Cardiovascular Disease.
Possible Mechanisms
- Reduce susceptibility of the heart to ventricular arrhythmia
- Antithrombogenic
- Hypotriglyceridemic (fasting and postprandial)
- Retard growth of atherosclerotic plaque
- Reduce adhesion molecule expression
- Reduce platelet-derived growth factor
- Antiinflammatory
- Promote nitric oxide-induced endothelial relaxation
- Mildly hypotensive
Side Effects and Safety
Several researchs are done to calculate optimal dose for its benefits.
Up to 1 g/d, there is a proven beneficial effects, and lower complication rates.
Above 3g/d, the complication effects overcome the benefits of the omega-3.
Some species of fish may contain significant levels of environmental contaminants. These substances bioconcentrate in the aquatic food chain such that levels are generally highest in older, larger, predatory fish and marine mammals.
These contaminants is longer half-life in the body and can accumulate in people who consume contaminated fish on a frequent basis and may impact our health.
For this may be, you should contact your dietitian our nutritionist, or is easier for you to choose a supplement.
Summary of Recommendation
Patients without documented CVD, Eat a variety of (preferably oily) fish at least twice a week. Include oils and foods rich in -linolenic acid (flaxseed, canola, and soybean oils; flaxseed and walnuts)
Patients with CVD, Consume up to 1 g of EPA DHA per day, preferably from oily fish. EPADHA supplementscould be considered in consultation with the physician.
Patients needing triglyceride lowering Two to four grams of EPADHA per day provided as capsules under a physician’s care.
Thank you for your appreciation.
Have a nice time
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