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Medicine is to heal from the inside

Healthy Food Improves Sperm Quality

Introduction
Infertility is a common case in daily life, approximately about 10% of couples, don't bear a child after 1 year. There are many factors that contributes to infertility such as male factor (mostly about the sperm), tubal occlusion, ovulation disturbance, etc.

In this article, i'm gonna focus on male factor or male infertility. There are many causes of male infertility. But i divided into simple category: anatomical causes, sperm, and genetics. Anatomical causes such as hypospadia, epispadia, erectile dysfunction, eventhough the man has a good quality of the sperm but it can be secreted correctly. While the genetics causes such as Klinefelter Syndrome, Kallmann Syndrome are the most difficult one.


I'm gonna focus on the sperm, male only contribute in reproduction via the sperm, while the female also contribute for the development of the embryo inside their womb.

Eventhough, its only contribute in beginning of reproduction, but the incidence of male infertility related to sperm quality is quite high about 25% of all causes. Therefore, finding a way to improve the quality of sperm is important in the treatment of infertility.
Sperm Quality

Diet and Sperm
Usual purpose of a married couples is about to have a child. But, less men know about sperm are greatly affected by diet and lifestyle choices. Most men aren't aware that smoking, drinking alcohol, and recreational drug use, all have a devastating effect on sperm health and reducing sperm count.


Additionally, many environmental factors have a hand in lowering sperm count and sperm motility. All these factors may help explain why men's sperm count is steadily declining throughout all industrialized countries. Research indicates that sperm counts have declined as much as 42% just in the last few decades.

An improper diet can mean that your sperm count is low or your sperm are damaged. People who drink alcohol often have lower sperm count. An element in the breakdown of alcohol is even toxic to sperm. Caffeine is another food that has been linked to sperm motility problems and chromosomal abnormalities.

Low antioxidant intake is associated with low reproductive capacity in semen. Spanish research study, published in March, showed that men who eat large amounts of meat and full fat dairy products have lower seminal quality than those who eat more fruit, vegetables and reduced fat dairy products.
Unhealthy Sperm

Way to improve the quality
Fortunately, sperm also can be affected in positive way through the lifestyle and diet. But in order to understand how important diet lifestyle changes are to sperm, you first need to know a very important fact. Sperm quality determine by its quantity (not less than 20 millions), its motility, and its shape. It takes 100 days for sperm to replenish.

There are some definite things you need to cut out of your diet and lifestyle immediately and during the entire time you are trying to conceive.

A healthy diet is not only a good way of avoiding illness, but could also have an impact on improving seminal quality. Nutritional solutions are available for problems with sperm count, sperm morphology, sperm motility, and sperm clumping.

First of all, stick to olive and sesame seed oil; cotton seed oil, in particular has been linked to decreased sperm production. Other things that low sperm count are smoking, food coloring, dioxins, trans-fats, and too vigorous exercise. Vitamin C is beneficial to sperm count, motility, and morphology, as well as for men who have sperm clumping. Garlic, whole grains, and nuts are also helpful. Nuts are particularly beneficial, because of their zinc content, and also because they are one for the very few foods containing arginine, which increases sperm count and motility.

There are many more foods and vitamins that can improve sperm quality.
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Pharmacotherapy for Premature Ejaculation

Introduction
Premature ejaculation (PE) is one of men's main concerns about his sexuality. Premature ejaculation often remains under-diagnosed and under-treated because of misperceptions by patients and physicians about its causes, lack of treatment modalities.
PE commonly occurs to a similar extent in men of all ages, compares to Erectile Dysfunction, that more often to be found in elderly.

PE is associated with short ejaculatory latency time, lack of ejaculatory control, decreased satisfaction of sexual intercourse, intrapersonal distress, a negative impact on a man’s self-esteem and reduced sexual function, and reduced quality of life. PE and ED as sexual dysfunction cause unsatisfaction sensation of sexual intercourse for man and his partner. Thus impact the relationship between both of them and give psychological pressure for man.
Premature ejaculation
adopted from http://male-ejaculation.net

PE symptoms are not only about the time for ejaculation, but also involving ejaculatory control, satisfaction of sexual intercourse, distress, and interpersonal difficulty.

PE can be either a lifelong condition (present since the onset of sexual maturity) or an acquired condition that develops after an interval of normal sexual function.

Underlying mechanism in PE is not well-known, concept of negative conditioning and penile hypersensitivity have been proposed as aetiological factors in PE, but still not enough evidence to support that. Besides that, there are no recognized organic diseases that linked with PE compare with Erectile problems.

Notably, the physiology of ejaculation is often unimpaired in patients with PE, and it is the lack of voluntary control of, and the short time to ejaculation after vaginal penetration those the focus of the problem in PE.

It has been postulated that PE might have a sensory/neural component involving perturbations in the serotonergic (5-hydroxytryptamine, 5-HT) system, this concept could contribute in PE pathogenesis.

Physiology of ejaculation
Normal ejaculation involves the processes of emission and expulsion of semen, which are coordinated by a network of afferent and efferent neural pathways.
Tactile stimulation of glans penis and various stimuli at other sensual sites and brain imagination trigger an ejaculation process.
Our ejaculatory control centres are located within the spinal cord, and responsive to peripheral dan brain stimulation. And have major function to coordinate, the sympathetic, parasympathetic, and somatic outputs to the pelviperineal anatomical structures participating in the emission and expulsion phases.
Serotonin neurophysiology
adopted from http://www.sciencedaily.com

Certain brain structures have been identified as related to sexual activity especially ejaculation process. In the brainstem, the nucleus paragigantocellularis, which contains a high concentration of serotonergic neurones, is shown to have a strong inhibitory role in the control of ejaculation. The periaqueductal grey has been shown, in an experimental animal system, to control the expulsion reflex.

Regulation of the ejaculatory reflex at the level of the spinal cord requires that coordinated neurochemical interrelationships take place at different levels of the neuraxis. Several neurotransmitter systems distributed throughout the supraspinal and spinal regions have been implicated in this process, with the 5-HT (serotonin) and dopaminergic neurones playing a primary role,

The neural pathways in ejaculation process is complex, involing many neurotransmitter and various neural structures, thus contributes to difficulty in determining of precise mechanism of ejaculation process.

Serotonin (5-HT) has risen scientists concern about its role in ejaculation process. Serotonin has several kind of receptor with different kind of action.
Activation of presynaptic serotonin neurons causes shorten in ejaculation latency. Serotonin stimulations to post-synaptics neurons causes prolong of ejaculation latency. Thus serotonin may play a major role in treatment.

Pharmacotherapy for PE
Pharmacotherapy or medical therapy can't guarantee an absolute cure for any kind of disease. But, with proper diagnosis and treatment perhaps it will give an optimal efforts in treating someone disease.

In modern era, pharmacotherapy is based on evidence based medicine or based on clinical trials measuring the efficacy of the proposed drugs, not by guessing or empirical.

Topical Agents
Topical lidocaine/prilocaine formulations are effectively cause desensitization, and have been shown to increase the mean in ejaculation latency in several trials. Mostly its effects on ejaculation related to desensitization of penis to stimuli, thus prolong the latency time for ejaculation. Side effects of this modality is numbness, burning sensation and rarely erection problem.

Sildenafil or Viagra
Sildenafil or viagra is shown doesn't have significant evidence in patient with PE, since it doesn't prolong the latency of ejaculation. But it can be used in combination with SSRI anti-depressants, especially in patients with concominant Premature ejaculation and erectile dysfunction. Viagra provides better sexual satisfaction and ejaculation control.

Clomipramine
Clomipramine is a tricyclic antidepressant that inhibits the uptake of noradrenaline and 5-HT by adrenergic and 5-HT neurones.
Continuous dosing with clomipramine significantly lengthened ejaculation latency compare with placebo.
After daily treatment with clomipramine, men with PE reported improved relationship and emotional satisfaction, men and their partners reported increased sexual satisfaction, and the partners reported an increased ability to achieve coital orgasm.

Usage of clomipramine in daily dosing might be limited by its associated side-effects. During continuous dosing, the adverse event of clomipramine in men with PE was reported to be significantly worse than with selective serotonin reuptake inhibitor (SSRI) treatment. Most annoying side-effects include sleepiness, yamning and nausea.

SSRIs antidepressants
Based on the role of serotonin in the physiology of ejaculatory control and possibly in the pathogenesis of PE, SSRIs antidepressants have become potential treatment for patient with premature ejaculation.

Currently marketed SSRIs such as paroxetine, fluoxetine, and sertraline, which increase synaptic Serotonin concentration via blockade of 5-HT transporters, have been investigated in numerous clinical studies for managing PE. The results are promising, SSRIs prolong ejaculation and give better sexual satisfaction than previous generation clomipramine.
American Urologic Association published current guidelines and recommendation for management of PE, and admitted SSRIs for PE treatment.

The Side-effects have been a major concern with the chronic use of SSRIs in patients with depressive disorders/symptoms, many of which have prompted discontinuation from therapy. The adverse effects of SSRIs include psychiatric and neurological consequences, dermatological reactions, anticholinergic
side-effects, changes in body weight, cognitive impairment.

Considering the shortcomings of chronic SSRI treatment, an optimal therapy for PE would have a short duration of activity, with clinical efficacy after each dose for on-demand treatment with no need for lead-in dosing.
Premature Ejaculation cartoon
adopted from http://www.powerbro.com/

Conclusion
Premature ejaculation is major concern of sexual medicine, not only for male but also for female. Inability to get sexual satisfaction will give a bad consequences of daily live, such as relationship problem with partner, depressed, loss of self-esteem, and poor quality of live.

Eventhough, premature ejaculation has a lot of consequences not only physical but also psychological and social, many patients still under-diagnosed and under-treated.

Pharmacotherapy using drugs doesn't guarantee 100% cure for any kind of disease, but it guarantee the best efforts of human knowledge to cure the disease.
SSRIs usage in treatment PE is promising, since its role in ejaculation is well described, but side-effects of chronic usage become the problem.
Proper dosing and short duration of activity SSRIs maybe an optional treatment in the future to overcome side-effects of SSRI.

Source: British Journal of Urology International 2008
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Watermelon as Man's Secret

Erectile Dysfunction
Erectile dysfunction is a condition when someone unable to produce or maintain sustainable erection firm enough for sexual intercourse. Mostly men experience this symptoms at some point in their, usually it happens by 40, and not psychologically affected by it.

However, some men, experience chronic, complete erectile dysfunction, and others, partial or brief erections. Having erectile dysfunction, can cause serious emotional and relationship problems, and often leads to depressed and loss of self-esteem.
Man's Hope

You are not alone
According to health epidemiological data, it's estimated about 30 million men in US experience chronic erectile dysfunction and incidence is increasing with ages. Chronic ED affects about 4% of men in their 50s, nearly 17% in 60s, and about 47% in age more than 75.
But, transient dysfunction and inadequate erection, occurs up to 50% of men between the ages of 40 and 70. So, after all. It is common health problem of man, and becomes man's secret.


The Causes
There many causes of this problems, one of the most common is diabetes.
It's about 20-70% of men with diabetes have problem with erection. They are about 2-3 times more likely to have that problem, and also pretend to experience it earlier about 10-15 years. Erectile dysfunction also maybe an early marker of diabetes in men ages 45 and younger.

Besides diabetes, other major causes of erectile dysfunction include high blood pressure, kidney disease, alcohol abuse, neurological problems (stroke, spinal cord trauma) and blood vessel disease. Erectile dysfunction may also occur because of the side effects of medications, psychological factors, smoking, and hormonal deficiencies.

One of big concern in ED is that loss of self-esteem, frustated that will further impact the disease, caused by one of stimulation of erection is our mind (libido). Lack of sexual desire, will impact sexual arousal in the context is erection.

Steps to Do
Men who experience erectile dysfunction, should consult his health care provider, to evaluate his condition. Eventhough is a small case, but it maybe an early sign of more serious health problem.
Then, the doctor may ask about the patient's medical history, the type and frequency of sexual problems, medications, smoking and drinking habits, and other health conditions. A physical exam and laboratory tests may help pinpoint causes of sexual problems.
A person will undergo check for blood glucose and hormone levels and may ask the patient to do a test at home that checks for erections that occur during sleep. And also may be asked about whether the patient is depressed or has recently experienced problems that disturbing his mind, emotional, and psychologically.
After patient condition is being diagnosed, the doctor will discussed about your condition and offering treatment modalities such as using pills, pump, surgery, and so on.

Role of Watermelon
Watermelon is a juicy fruit that tastes great and thrist quenching in nature, caused of its water content. Appart from is tastes, watermelon also contains several minerals and vitamin that important to maintain our health, such as Vitamin AVitamin C, Vitamin B1 and B6, Magnesium and Potassium.

Watermelon and impotence? How do they correlate.
Watermelon has a phytochemical component called citrulline that present in the rind portion of it. This citrulline has the ability to relax blood vessels throughout the body. Inside our body, citrulline is converted into arginine, arginine itself is a precursor of nitrous oxide our natural vessels dilator. Nitrous oxide dilates and relaxes our blood vessels, causing increase in blood flow to the penis and thus helps to solve erectile dysfunction.
Watermelon

To confirm the fact that watermelon can be helpful as impotence treatment, a study was conducted in which 200 men suffering with the impotence participated. Each of them was asked to daily eat 200gms of the watermelon for about a month and then after a month period they were asked about their performance during the sex. It was observed that 43% of the men were able to get the better erections than before. These men were able to last longer during the sexual encounter and there sexual stamina was also found to be boosted.

Summary
So, daily intake about 200 grams of Watermelon maybe good to enhance your sexual appetite and culminate the impotence.

But, there is need to do more research about it, since it is lack of proof.
Anyway, Watermelon contains much components that may helps us to maintain health, such vitamin, minerals, water, etc.
So, it's okay to try it. Since it better and healthier than smoking.

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Aspirin as a new paradigm in Prostate Cancer

Important of Prostate Cancer
Prostate cancer is a malignant tissue growth that consists of cells from the prostate gland. Generally, the tumor usually grows slowly and remains confined to the gland for many years. But, some type of prostate cancer are more aggressive, thus are more rapid grow and spread, so give more significant shortening of life expectancy in men affected by them.
Healthy Men and his wife

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