yulius hermanto
Soursup as anti-Cancer
Introduction
Soursop (Annona muricata) is a broadleaf flowering evergreen tree native to latin america. Soursop is also native to sub-Saharan African countries that lie within the tropics. Today, it is also grown in some areas of Southeast Asia. Its flavor has been described as a combination of strawberry and pineapple with sour citrus flavor notes contrasting with an underlying creamy flavor reminiscent of coconut or banana.
Nowadays, Soursop or the fruit from the graviola tree is linked to a miraculous natural cancer cell killer that 10,000 times stronger than Chemotherapy, there a lot of website publishing about this. Most of the website, said that soursop research about cancer is being covered by some some big corporations want to make back their money spent on years of research by trying to make a synthetic version of it for sale.
I'm not gonna discuss about whether there is big conspirations or not, but about the fact of anti-cancer properties of soursop.
Anti-cancer properties
There is only little information about soursop research related to anti-cancer.
I'll try to summarize those researchs.
First, a study that published in the Journal of Natural Products, following a recent study conducted at Catholic University of South Korea, stated that one chemical in Graviola was found to selectively kill colon cancer cells at, 10,000 times the potency of (the commonly used chemotherapy drug) Adriamycin.
The most significant part of the Catholic University of South Korea report is that Graviola was shown to selectively target the cancer cells, leaving healthy cells untouched, unlike chemotherapy which indiscriminately targets all actively reproducing cells (such as stomach and hair cells) causing the often devastating side effects of nausea and hair loss in cancer patients.
Another study about soursop was conducted by Purdue University, found that leaves from the Graviola tree killed cancer cells among six human cell lines and were especially effective against prostate, pancreatic and lung cancers.
Jerry L McLaughlin, a scientist from Purdue University found a active compound in soursop leaf, "acetogenins". Acetogenins trial has been done pre-clinicallnya, or in-vitro study that can kill cancer cell selectively. Acetogenins inhibits ATP (adenosine triphosphates). ATP itself, is a energy source for the cell. Cancer cell needs a lot of ATP for its growth and proliferations thus can be killed by acetogenins.
Those researchs looks like so dramatic, but it is a fact or not? And if it a fact, does it applicable?
Well, its maybe true if soursop have anti-cancer properties, especially the acetogenins. Acetogenins can inhibits ATP, stated by one study. But, most of the research is done in-vitro, or just pre-clinical studies and mostly only in laboratory. And most of the research only used the cancer cells.
Cancer Cell can be killed even with a water or by oil, but the problems is how to spare the normal cells.
ATP is important component of cell, whether cancer or normal cell. If a drug inhibits ATP production is not kill the cancer but also kill the normal cell, instantly. Another component that can inhibits our body energy synthesis is cyanide, one of the deadly toxin.
Another things that need to criticize, Cancer therapy or drug invention isn't a simple process like old times, since we face with human, a living organism. We can't easily try any drugs. A drug needs to pass severals trials before used widely or get FDA approved.
Most of the latest invention is about chemical modification of previous drugs, since a new invention of products need about 10-30 years to be accepted or to pass all the clinical trials and needs lot of money.
Perhaps the soursop research about anti-cancer is about the early phase, and still long ways to go to be accepted. Some anti-cancer chemotherapy also found from herbal, such oncovin. And it is also expensive, since the process of extraction and the cost of production.
Conclusion
I can't accept Soursop as anti-cancer directly, since the complete clinical trial is not been done or completed. Thus can't be applied into daily practice, yet.
Maybe there are some testimonials about soursop as anticancer, whether is true or not, its difficult to be proved. But we need to criticize any reports especially reports with insufficent or less sytematic evidence.
Soursop (Annona muricata) is a broadleaf flowering evergreen tree native to latin america. Soursop is also native to sub-Saharan African countries that lie within the tropics. Today, it is also grown in some areas of Southeast Asia. Its flavor has been described as a combination of strawberry and pineapple with sour citrus flavor notes contrasting with an underlying creamy flavor reminiscent of coconut or banana.
Nowadays, Soursop or the fruit from the graviola tree is linked to a miraculous natural cancer cell killer that 10,000 times stronger than Chemotherapy, there a lot of website publishing about this. Most of the website, said that soursop research about cancer is being covered by some some big corporations want to make back their money spent on years of research by trying to make a synthetic version of it for sale.
I'm not gonna discuss about whether there is big conspirations or not, but about the fact of anti-cancer properties of soursop.
Anti-cancer properties
There is only little information about soursop research related to anti-cancer.
I'll try to summarize those researchs.
First, a study that published in the Journal of Natural Products, following a recent study conducted at Catholic University of South Korea, stated that one chemical in Graviola was found to selectively kill colon cancer cells at, 10,000 times the potency of (the commonly used chemotherapy drug) Adriamycin.
The most significant part of the Catholic University of South Korea report is that Graviola was shown to selectively target the cancer cells, leaving healthy cells untouched, unlike chemotherapy which indiscriminately targets all actively reproducing cells (such as stomach and hair cells) causing the often devastating side effects of nausea and hair loss in cancer patients.
Another study about soursop was conducted by Purdue University, found that leaves from the Graviola tree killed cancer cells among six human cell lines and were especially effective against prostate, pancreatic and lung cancers.
Jerry L McLaughlin, a scientist from Purdue University found a active compound in soursop leaf, "acetogenins". Acetogenins trial has been done pre-clinicallnya, or in-vitro study that can kill cancer cell selectively. Acetogenins inhibits ATP (adenosine triphosphates). ATP itself, is a energy source for the cell. Cancer cell needs a lot of ATP for its growth and proliferations thus can be killed by acetogenins.
Those researchs looks like so dramatic, but it is a fact or not? And if it a fact, does it applicable?
Well, its maybe true if soursop have anti-cancer properties, especially the acetogenins. Acetogenins can inhibits ATP, stated by one study. But, most of the research is done in-vitro, or just pre-clinical studies and mostly only in laboratory. And most of the research only used the cancer cells.
Cancer Cell can be killed even with a water or by oil, but the problems is how to spare the normal cells.
ATP is important component of cell, whether cancer or normal cell. If a drug inhibits ATP production is not kill the cancer but also kill the normal cell, instantly. Another component that can inhibits our body energy synthesis is cyanide, one of the deadly toxin.
Another things that need to criticize, Cancer therapy or drug invention isn't a simple process like old times, since we face with human, a living organism. We can't easily try any drugs. A drug needs to pass severals trials before used widely or get FDA approved.
Most of the latest invention is about chemical modification of previous drugs, since a new invention of products need about 10-30 years to be accepted or to pass all the clinical trials and needs lot of money.
Perhaps the soursop research about anti-cancer is about the early phase, and still long ways to go to be accepted. Some anti-cancer chemotherapy also found from herbal, such oncovin. And it is also expensive, since the process of extraction and the cost of production.
Conclusion
I can't accept Soursop as anti-cancer directly, since the complete clinical trial is not been done or completed. Thus can't be applied into daily practice, yet.
Maybe there are some testimonials about soursop as anticancer, whether is true or not, its difficult to be proved. But we need to criticize any reports especially reports with insufficent or less sytematic evidence.
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Yes, more objectives references are needed in order to accept an issue as an proof.