yulius hermanto
Stem Cells May Improve Heart Bypass Results
Is That True?
On Nov 17th 2008, German Researchers publish their result of their studies.
They said that Patients who received bone marrow stem cell transplants during coronary bypass surgery (CABG) experienced "excellent long-term safety and survival,"
The study included 35 patients who get stem cell transplantation during CABG, 20 patients who received only CABG surgery.
Long-term survival among patients in the stem cell transplant/CAGB group was up to five years.
Stem Cell Transplant as a new hope
Stem Cell is a novel technology that being developed recently to overcome the problem in therapy in some disease.
Stem Cell itself is a multipotent cell that arise from genetic engineering from our body's tissue. It behave just like an embryo, proliferate and differentiate.
But, for our purpose the differentiation of the stem cell can be set up to one kind of tissue such as: nerve tissue, vessels, etc.
But, in this article i will discuss about stem cell in heart disease.
Cell transplantation has the potential to become but one of the new and exciting therapies for the treatment of patients with chronic heart failure.
One explanation may be that although many kinds of heart disease can be successfully treated, they are not truly cured. A good example is the patient who has an acute myocardial infarction (heart attack, MI) with significant myocardial (heart muscle injury). While reperfusion therapy, such as angioplasty or coronary artery bypass grafting, will prolong survival,
The permanent myocardial damage cause by infarction will have such a remodelling that gonna lead to changes in the heart's left ventricle not only the shape but also the function, resulting in heart failure. Thus will give an additional impact on morbidity.
Our body has an amazing ability to repair itself. When injury occurs, the body sends special cells (natural stem cells, produced by the bone marrow) to the site that calls for healing. These cells, help remove dead cells and repair the injured tissue. For some reason, the heart does not have the same process for healing itself.
In the past decade, researchers have been testing the ability to utilize cells to rebuild the heart after injury. Early research looked at transplantation of fetal or embryonic stem cells, as well as myoblasts (immature muscle cells). While fetal stem cells have promise, the widespread clinical application of this approach is limited due to the ethical dilemma of the use of embryonic and fetal tissue as well as the issue of chronic rejection.
The skeletal muscle cells, an autogenic source, recovered from the recipient's own body, have the advantage of being a readily available and unlimited source without the risk of rejection. The myoblasts are harvested from the patient's thigh, processed in the lab, and injected into the heart. Prior studies showed that processed myoblasts demonstrate the ability to become functioning heart muscle cells, as well as proliferate and send signals to attract additional stem cells to repair damaged heart muscle.
Is This Technology can be used?
Hmm, actually i don't know how to answer this.
because in my country this technology is very expensive, and also the experts are rare.
I think this technology is a promising one.
To implant a stem cell to someone body isn't a simple procedure. It may through several steps before it done. And mostly done in laboratory.
But for more information, you can consult your cardiologist.
On Nov 17th 2008, German Researchers publish their result of their studies.
They said that Patients who received bone marrow stem cell transplants during coronary bypass surgery (CABG) experienced "excellent long-term safety and survival,"
The study included 35 patients who get stem cell transplantation during CABG, 20 patients who received only CABG surgery.
Long-term survival among patients in the stem cell transplant/CAGB group was up to five years.
Stem Cell Transplant as a new hope
Stem Cell is a novel technology that being developed recently to overcome the problem in therapy in some disease.
Stem Cell itself is a multipotent cell that arise from genetic engineering from our body's tissue. It behave just like an embryo, proliferate and differentiate.
But, for our purpose the differentiation of the stem cell can be set up to one kind of tissue such as: nerve tissue, vessels, etc.
But, in this article i will discuss about stem cell in heart disease.
Cell transplantation has the potential to become but one of the new and exciting therapies for the treatment of patients with chronic heart failure.
One explanation may be that although many kinds of heart disease can be successfully treated, they are not truly cured. A good example is the patient who has an acute myocardial infarction (heart attack, MI) with significant myocardial (heart muscle injury). While reperfusion therapy, such as angioplasty or coronary artery bypass grafting, will prolong survival,
The permanent myocardial damage cause by infarction will have such a remodelling that gonna lead to changes in the heart's left ventricle not only the shape but also the function, resulting in heart failure. Thus will give an additional impact on morbidity.
Our body has an amazing ability to repair itself. When injury occurs, the body sends special cells (natural stem cells, produced by the bone marrow) to the site that calls for healing. These cells, help remove dead cells and repair the injured tissue. For some reason, the heart does not have the same process for healing itself.
In the past decade, researchers have been testing the ability to utilize cells to rebuild the heart after injury. Early research looked at transplantation of fetal or embryonic stem cells, as well as myoblasts (immature muscle cells). While fetal stem cells have promise, the widespread clinical application of this approach is limited due to the ethical dilemma of the use of embryonic and fetal tissue as well as the issue of chronic rejection.
The skeletal muscle cells, an autogenic source, recovered from the recipient's own body, have the advantage of being a readily available and unlimited source without the risk of rejection. The myoblasts are harvested from the patient's thigh, processed in the lab, and injected into the heart. Prior studies showed that processed myoblasts demonstrate the ability to become functioning heart muscle cells, as well as proliferate and send signals to attract additional stem cells to repair damaged heart muscle.
Is This Technology can be used?
Hmm, actually i don't know how to answer this.
because in my country this technology is very expensive, and also the experts are rare.
I think this technology is a promising one.
To implant a stem cell to someone body isn't a simple procedure. It may through several steps before it done. And mostly done in laboratory.
But for more information, you can consult your cardiologist.
